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Pyridoxamine Hydrochloride for Pharmaceutical Intermediates

Product Detail Information
Product Description
Pyridoxamine dihydrochloride

Quick detail:
Chinese Synonyms: 4-amino-methyl-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride; pyridoxamine hydrochloride; 
English name: Pyridoxamine dihydrochloride
Synonyms: 2-methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridenedihydrochloride;
CAS: 524-36-7
Formula: C8H14Cl2N2O2
Molecular Weight: 241.11
EINECS Number: 208-357-6
Nature white flaky crystal, hygroscopic, stable at room temperature, see light gradually change color. Mp226-227 ºC (decomposition), has a maximum absorption at 287.5nm wavelength. Soluble in ethanol, soluble in water.
Use biochemical research, pharmacological effects with vitamin B6.

Description:
Vitamin B6 include pyridoxine, pyridoxine and pyridoxamine, in the body by adenosine triphosphate by the action of enzymes form a active pyridoxal phosphate and phosphate pyridoxamine (pyridoxine phosphorylated after can also be converted to pyridoxal phosphate aldehydes) are both coenzyme various transaminase, pyridoxal phosphate can be passed through the body with the effect of pyridoxamine phosphate interconversion manner sky group, which catalyze the conversion of amino acids and amino acid α- between. Pyridoxal phosphate is certain amino acid decarboxylase and δ- amino -γ- ALA synthase coenzyme. Glutamic acid decarboxylase catalyzes the conversion of inhibitory neurotransmitter γ- aminobutyric acid; δ- amino -γ- ALA, followed by the action of a series of enzymatic synthesis of heme. In addition to vitamin B6 is also involved in fat metabolism, and promote the growth of white blood cells and so on.

Application:
 Vitamin B6 has been reported for patients with diabetes, thereby improving clinical symptoms, some scholars believe that the United States women taking birth control pills should also take vitamin B6, and recommended when increasing age, the vitamin B6 intake also increases.
Production methods pyridoxine hydrochloride by manganese dioxide oxidation, and hydroxylamine condensation, and then zinc metal reduction.